بسم الله الرحمن الرحيم
The tissue paper which you keep after doing istinja they turned impure, it is not lawful to use them.If the urine exceeds the place of the urine then it is not enough to clean it with tissue paper, rather it is necessary to wash it with water.
(2) Take 10-10 grams of ‘Majun Masikul Baul’ of Hamdard in the morning and evening with water. In-shaAllah you shall get cured.
Allah knows Best!
Darul Uloom Deoband